Chatham University

Biochemistry Curriculum

Biochemistry is a science whose boundaries now encompass many aspects of chemistry and biology, from molecules and cells to organisms and ecology. Scientists use the tools of biochemistry and molecular biology to explore cures for disease, improve public health, remediate environmental pollution, and develop cheaper and safer natural products. The program is approved by the American Chemical Society and is ideal for students who are planning graduate work in biochemistry or molecular biology, seeking jobs in biotechnology, or applying to medical school. An accelerated program is available for students to obtain a B.S. in Biochemistry from Chatham and a M.S. in Forensics Science and Law from Duquesne University; check with the department chair for details.

Program Requirements

+ Major Requirements (B.A. Degree)

50 credits, including:
BIO143 The Cell

This course is designed to provide a broad overview of current biological concepts, including cell structure, function, division, and basic genetics. Biologically important molecules also are presented. This course is a prerequisite for all upper-level biology courses. Three hours of class

3
BIO143L Lab: The Cell

Experiments to complement the material presented in BIO143. Two hours of laboratory per week. Corequisite or prerequisite: BIO143. Additional Fee(s): Laboratory fee.

1
BIO144 The Organism

This course provides a general survey of animals and plants at the organismic level, with emphasis on their evolution and various physiological processes such as respiration, circulation, digestion, and reproduction. This course is a prerequisite for all upper-level biology courses. Three hours of class.

3
BIO144L Lab: The Organism

Experiments to complement the material presented in BIO144. Two hours of laboratory per week. Corequisite or prerequisite: BIO144. Additional Fee(s): Laboratory fees.

1
CHM105 General Chemistry

This class covers the same material as Chemistry 107 below, but is specifically structured for students who have had little or no previous chemistry experience, or who need extra help with algebraic problem solving. Three hours of lecture and one hour of recitation per week. Co-requisite: CHM 109

3
CHM107 Chemistry I

This class begins with a study of atomic structure, then expands to cover chemical naming, patterns of reactivity, thermochemistry, the interaction of light and matter, atomic orbitals, ionic and covalent bonding, and molecular shapes. This class concludes with an introduction to organic chemistry and biochemistry. Three hours of lecture per week. Co-requisite: CHM 109

3
CHM108 Chemistry II

The second semester of general chemistry continues exploring the structure, properties, and bonding of atoms and molecules, with emphasis on the physical characteristics of gases, liquids, solids and solutions, chemical equilibria, thermodynamics, and kinetics. Three hours of lecture per week. Prerequisite(s): CHM 105 or 107; Corequisite: CHM 110.

3
CHM109 Chemistry I Laboratory

Introduction to the basic experimental procedures and laboratory techniques in chemistry. Experiments are correlated with the lectures in Chemistry 105 and Chemistry 107. Three hours of laboratory per week. Corequisite: CHM 105 or 107. Additional Fee(s): Laboratory fee.

1
CHM110 Chemistry II Laboratory

Continued introduction to the basic experimental procedures and laboratory techniques in chemistry. Experiments are correlated with lectures in Chemistry 108. Three hours of laboratory per week. Corequisite: CHM 108. Additional Fee(s): Laboratory fee.

1
CHM205 Organic Chemistry I

Development of the structural theory of organic compounds. Relationship of structure to reactivity, stereochemistry, types of organic reactive intermediates, and the chemistry of alkanes, alkenes, and aromatic compounds are covered. Three hours of lecture per week. Prerequisite(s): CHM 108 and 110; Co-requisite: CHM 215.

3
CHM206 Organic Chemistry II

Discussion of organic functional groups and their chemistry. Spectroscopy, mechanisms, and synthetic type-reactions are included. A discussion of biologically important compounds is covered during the last third of the term. Prerequisite(s): CHM 205 and 215

3
CHM215 Elementary Organic Laboratory

Basic manipulative skills, including introduction to several chromatographic techniques, are followed by chemistry of alkenes and aromatic compounds. Four hours of laboratory per week. Prerequisite(s): CHM 205. Additional Fee(s): Laboratory fee.

2
CHM216 Organic Chemistry Laboratory

Chemistry of organic functional groups. Identification of unknowns and a multistep synthesis. Four hours of laboratory per week. Prerequisite(s): CHM 215; Co-requisite: CHM 206. Additional Fee(s): Laboratory fee.

2
CHM338 Biochemistry I

This course covers the structure and functions of proteins, polynucleic acids, and biological membranes. Enzymes and kinetics are taught. Metabolic pathways, with emphasis on the thermodynamics of the equilibria and the storage and usage of energy, are covered. Three hours of lecture per week. Prerequisite(s): CHM 206 or permission of the instructor.

3
CHM339 Biochemistry II

Metabolism is studied with an emphasis on anabolic pathways and special pathways such as cytochrome P450. Other topics include molecular genetics and protein synthesis, hormones and receptors, and immunology. Three hours of lecture per week. Cross-listed as BIO438 Prerequisite(s): CHM 338

3
CHM340 Macromolecule Laboratory

An advanced laboratory course for junior and senior science majors who wish to gain theoretical and practical experience with the techniques and equipment commonly used in the fields of cellular biology, molecular biology, and biochemistry. Topics include PCR, electrophoresis, enzyme kinetics, aseptic cell and tissue culture, cell surafce receptors, and molecular modeling. Five-hour laboratory with one-hour pre-lab lecture each week. Cross-listed as BIO 440. Prerequisite(s): BIO431 or CHM 338; or permission of the instructor. Additional Fee(s): Laboratory fee.

2
CHM498 Tutorial: Chemistry

4
CHM499 Tutorial: Chemistry

4
BIO498 Tutorial: Biology

4
BIO499 Tutorial: Biology

4
IND350 Scientific Research Methods

This course serves as an introduction to research literature and research methodology in the sciences. Students prepare a research proposal including literature review, experimental design and methods, budget, timetable, and bibliography. Other topics include professional presentation techniques and research ethics. The student's major department must approve proposals prior to the Tutorial. Prerequisite(s): Junior status and completion of at least two courses at the 200-level or above in the major, or permission of the instructor.

2

3 credits of biology at the 200-level or above.
3 credits of chemistry at the 300-level or above.

+ Major Requirements (B.S. Degree)

79 credits, including:
BIO143 The Cell

This course is designed to provide a broad overview of current biological concepts, including cell structure, function, division, and basic genetics. Biologically important molecules also are presented. This course is a prerequisite for all upper-level biology courses. Three hours of class

3
BIO143L Lab: The Cell

Experiments to complement the material presented in BIO143. Two hours of laboratory per week. Corequisite or prerequisite: BIO143. Additional Fee(s): Laboratory fee.

1
BIO144 The Organism

This course provides a general survey of animals and plants at the organismic level, with emphasis on their evolution and various physiological processes such as respiration, circulation, digestion, and reproduction. This course is a prerequisite for all upper-level biology courses. Three hours of class.

3
BIO144L Lab: The Organism

Experiments to complement the material presented in BIO144. Two hours of laboratory per week. Corequisite or prerequisite: BIO144. Additional Fee(s): Laboratory fees.

1
CHM105 General Chemistry

This class covers the same material as Chemistry 107 below, but is specifically structured for students who have had little or no previous chemistry experience, or who need extra help with algebraic problem solving. Three hours of lecture and one hour of recitation per week. Co-requisite: CHM 109

3
CHM107 Chemistry I

This class begins with a study of atomic structure, then expands to cover chemical naming, patterns of reactivity, thermochemistry, the interaction of light and matter, atomic orbitals, ionic and covalent bonding, and molecular shapes. This class concludes with an introduction to organic chemistry and biochemistry. Three hours of lecture per week. Co-requisite: CHM 109

3
CHM108 Chemistry II

The second semester of general chemistry continues exploring the structure, properties, and bonding of atoms and molecules, with emphasis on the physical characteristics of gases, liquids, solids and solutions, chemical equilibria, thermodynamics, and kinetics. Three hours of lecture per week. Prerequisite(s): CHM 105 or 107; Corequisite: CHM 110.

3
CHM109 Chemistry I Laboratory

Introduction to the basic experimental procedures and laboratory techniques in chemistry. Experiments are correlated with the lectures in Chemistry 105 and Chemistry 107. Three hours of laboratory per week. Corequisite: CHM 105 or 107. Additional Fee(s): Laboratory fee.

1
CHM110 Chemistry II Laboratory

Continued introduction to the basic experimental procedures and laboratory techniques in chemistry. Experiments are correlated with lectures in Chemistry 108. Three hours of laboratory per week. Corequisite: CHM 108. Additional Fee(s): Laboratory fee.

1
CHM205 Organic Chemistry I

Development of the structural theory of organic compounds. Relationship of structure to reactivity, stereochemistry, types of organic reactive intermediates, and the chemistry of alkanes, alkenes, and aromatic compounds are covered. Three hours of lecture per week. Prerequisite(s): CHM 108 and 110; Co-requisite: CHM 215.

3
CHM206 Organic Chemistry II

Discussion of organic functional groups and their chemistry. Spectroscopy, mechanisms, and synthetic type-reactions are included. A discussion of biologically important compounds is covered during the last third of the term. Prerequisite(s): CHM 205 and 215

3
CHM215 Elementary Organic Laboratory

Basic manipulative skills, including introduction to several chromatographic techniques, are followed by chemistry of alkenes and aromatic compounds. Four hours of laboratory per week. Prerequisite(s): CHM 205. Additional Fee(s): Laboratory fee.

2
CHM216 Organic Chemistry Laboratory

Chemistry of organic functional groups. Identification of unknowns and a multistep synthesis. Four hours of laboratory per week. Prerequisite(s): CHM 215; Co-requisite: CHM 206. Additional Fee(s): Laboratory fee.

2
CHM311 Physical Chemistry I

Thermodynamic descriptions of chemical systems, emphasizing gases and solutions. Phase transitions and phase equilibria, chemical equilibria, kinetics, and electrochemistry. Three hours of lecture per week. Prerequisite(s): CHM 205 and 215; MTH 152; and PHY 252.

3
CHM317 Integrated Chemistry Laboratory

Experiments are selected to illustrate important principles of advanced experimental chemistry and familiarize students with important experimental methods. The course is intended to encourage students to think critically about the reliability of their experimental results in the light of their previous chemistry experience. Five hours of laboratory per week. Prerequisite(s): CHM 216 Additional Fee(s): Laboratory fee.

2
CHM322 Topics in Analytical Chemistry

This course explores the fundamental chemical principles underlying modern chemical instrumentation. Students learn the advantages and limitations of these instruments, how to select the proper instrumental configuration for a specific experiment, and how to evaluate emerging chemical technologies. Three hours of lecture per week. Prerequisite(s): CHM 215; Co-requisite: CHM 318

3
CHM338 Biochemistry I

This course covers the structure and functions of proteins, polynucleic acids, and biological membranes. Enzymes and kinetics are taught. Metabolic pathways, with emphasis on the thermodynamics of the equilibria and the storage and usage of energy, are covered. Three hours of lecture per week. Prerequisite(s): CHM 206 or permission of the instructor.

3
CHM339 Biochemistry II

Metabolism is studied with an emphasis on anabolic pathways and special pathways such as cytochrome P450. Other topics include molecular genetics and protein synthesis, hormones and receptors, and immunology. Three hours of lecture per week. Cross-listed as BIO438 Prerequisite(s): CHM 338

3
CHM340 Macromolecule Laboratory

An advanced laboratory course for junior and senior science majors who wish to gain theoretical and practical experience with the techniques and equipment commonly used in the fields of cellular biology, molecular biology, and biochemistry. Topics include PCR, electrophoresis, enzyme kinetics, aseptic cell and tissue culture, cell surafce receptors, and molecular modeling. Five-hour laboratory with one-hour pre-lab lecture each week. Cross-listed as BIO 440. Prerequisite(s): BIO431 or CHM 338; or permission of the instructor. Additional Fee(s): Laboratory fee.

2
CHM498 Tutorial: Chemistry

4
CHM499 Tutorial: Chemistry

4
BIO498 Tutorial: Biology

4
BIO499 Tutorial: Biology

4
IND350 Scientific Research Methods

This course serves as an introduction to research literature and research methodology in the sciences. Students prepare a research proposal including literature review, experimental design and methods, budget, timetable, and bibliography. Other topics include professional presentation techniques and research ethics. The student's major department must approve proposals prior to the Tutorial. Prerequisite(s): Junior status and completion of at least two courses at the 200-level or above in the major, or permission of the instructor.

2
MTH151 Calculus I

This is the first course in the calculus sequence. Topics include differential and integral calculus for algebraic and trigonometirc functions with applications. Four hours of class per week. Prerequisite(s): MTH 105 and 106, or MTH 108, or equivalent.

4
MTH152 Calculus II

This is the second course in the calculus sequence. Topics include differential and integral calculus for the transcendental functions, advanced methods of integration, and infinite sequences and series. Prerequisite(s): MTH 151

4
PHY251 Principles of Physics I

Introduction to the concepts, laws, and structure of physics. This is the first course in a calculus-based sequence that focuses on classical mechanics. Topics include vector analysis, kinematics, Newton’s laws, work, conservation of energy and momentum, collisions, gravity, harmonic motion, and wave phenomena. Prerequisite(s) or Corequisite: MTH 151.

4
PHY252 Principles of Physics II

Introduction to the concepts, laws, and structure of physics. The second course in a calculus-based physics sequence. Topics include thermodynamics, fluids, electricity, circuit analysis, magnetism, Maxwell’s equations, properties of light, and optics. Four hours of class per week.

Prerequisite(s): PHY 251

4
PHY255 Physics Laboratory I

Experimental techniques of classical mechanical physics. Three hours of laboratory per week.

Prerequisite(s): PHY 251

Additional Fee(s): Laboratory fee.

1
PHY256 Physics Laboratory II

Experimental techniques of classical physics with applications to electricity, magnetism, sound, and optics. Three hours per week.

Prerequisite or Corequisite: PHY 252.

Additional Fee(s): Laboratory fee.

1
2 courses from the following:
BIO221 General Microbiology

The study of fundamental characteristics of bacteria and related microorganisms, including taxonomy, physiology, and distribution. Three class meetings per week. Prerequisite(s): Chemistry 108 and 110.

3
BIO231 Cell and Molecular Biology

A lecture course covering the organelles and activities of cells. Topics include the structure of proteins and other biomolecules, bioenergetics and enzymes, membranes, the mitochondrion, the chloroplast, the endo-membrane system, the cytoskeleton, and the nucleus and cellular reproduction. Prerequisite(s): BIO143 and 144, and CHM 109 and 110

3
BIO417 Genetics

This study of the modern concepts of the gene stresses theory and experimental evidence relating to the structure of the gene, heritability of characteristics, and the behavior of genes in populations. Three hours of lecture per week.Prerequisite(s): BIO 143 and 144, and CHM 205 and 215. Statistics recommended.

3