Biology Faculty and Staff
Gary Marshall Ph.D.
Hometown : Cinncinati, OH
Joined Chatham : 2008
Academic Areas of Interest
Anatomy and Physiology, Reproductive Biology, Endocrinology, Cell Biology, Histology and Histomorphometry, Radioimmunoassay (RIA), Stereology
Personal Areas of Interest
Tai Chi Chuan, Orchid Growing, and Beekeeping
I was born and raised in southwestern Ohio near Cincinnati. I grew up in a rural area and roamed woods, fields, and river banks with my friends and my brother. I did well in school and was most interested in science, especially biology. I was not an athlete, but played little league baseball every summer until I entered high school. I met my wife, June, while we were both in high school. We were “high school sweethearts” and we later married in 1969. After we both graduated from the Ohio State University we moved to Houston, Texas where I attended graduate school and June started her career as a graphic designer. After adjusting to the heat and humidity of the Gulf coast, we loved the big city life. In 1977 we came to Pittsburgh for my post doctoral training and June continued her work as a graphic designer. In 1980, I was offered a position at the Max Planck Clinical Research Unit in Reproductive Medicine, Muenster, Federal Republic of Germany, usually called West Germany. June and I discussed for a few days and we decided to move there. I spoke very little German-June none, but that did not seem important. I still speak a very little German; June became very proficient in the language. We would not trade our five years in Germany, not only because of the people and culture, but our daughters , Jessica and Anneliese, were born there. We left Germany in 1985 about 18 months after Anneliese’s birth. We returned to Pittsburgh and have been here since.
- B. S , Ohio State University (Columbus, OH), 1970, M.S. University of Texas at Houston, (Houston TX), 1973, PH. D.The University of Texas at Houston (Houston, TX,, 1977
- Marshall G, and Brinkley BR: Dynamics of the seminiferous epithelium in mammals by ultrastructural analysis. Texas Rep. Biol. Med. 30:385, 1972.
- Knobil E, Plant TM, Wildt L, Belchetz PE and Marshall G: Neuroendocrine control of the rhesus monkey menstrual cycle: Permissive role of hypothalamic gonadotropin releasing hormone (GnRH). Science 207:1371, 1980.
- Wildt L, Marshall G and Knobil E: Experimental induction of puberty in the infantile female rhesus monkey. Science 207:1373, 1980.
- Wildt L, Hausler A, Hutchison JS, Marshall G and Knobil E: Estradiol is a gonadotropin releasing hormone in the rhesus monkey. Endocrinology 108:2011, 1981.
- Wildt L, Hausler A, Marshall G, Hutchison JS, Plant TM, Belchetz PE and Knobil E: Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology 109:376, 1981.
- Wildt L, Hutchison JS, Marshall G, Pohl CR and Knobil E: On the site of action of progesterone in the blockade of the estradiol-induced gonadotropin discharge in the rhesus monkey. Endocrinology 102:1293, 1981.
- Pohl CR, Richardson DW, Marshall G and Knobil E: Mode of action of progesterone in the blockade of gonadotropin surges in the rhesus monkey. Endocrinology 110:1454, 1982.
- Marshall GR and Wickings EJ: Bromocriptine, a dopamine agonist, inhibits hCG-stimulated testosterone production by mouse testicular cells in vitro. Acta Endocrinol. Suppl. (Copenh) 246:21, 1982.
- Bint Aktar F, Marshall GR, Wickings EJ and Nieschlag E: Reversible induction of azoospermia in rhesus monkeys by constant infusion of a GnRH agonist using osmotic minipumps, J. Clin. Endocrinol. Metab. 56:534, 1983.
- Huang HFS and Marshall GR: Failure of spermatid release under various vitamin A states--an indication of delayed spermiation. Biol. Reprod. 28:1163, 1983.
- Marshall GR, Wickings EJ, Luedecke DK and Nieschlag E: Stimulation of spermatogenesis in stalk-sectioned rhesus monkeys by testosterone alone. J. Clin. Endocrinol. Metab. 57: 152, 1983.
- Bint Akhtar F, Marshall GR and Nieschlag E: Testosterone supplementation attenuates the antifertility effects of an LHRH agonist in male rhesus monkeys. Int. J. Androl. 6:461, 1983.
- Marshall GR, Wickings EJ and Nieschlag E: Testosterone can initiate spermatogenesis in an immature non-human primate, Macaca fascicularis. Endocrinology 114:2228-2233, 1984.
- Marshall GR and Nieschlag E: Initiation, restoration and maintenance of spermatogenesis in non-human primates by testosterone. Ann N.Y. Acad Sci 438:549, 1984.
- Rea MA, Marshall GR, Weinbauer GF and Nieschlag E: Testosterone maintains pituitary and serum FSH and spermatogenesis in gonadoptropin-releasing hormone (GnRH) antagonist-suppressed rats. J. Endocr. 108: 101, 1986.
- Marshall GR, Bint Aktar F, Weinbauer GF and Nieschlag E: GnRH overcomes GnRH antagonist induced suppression on LH secretion in primates, J. Endocr. 110:145, 1986.
- Weinbauer GF, Marshall GR and Nieschlag E: New injectable testosterone ester maintains serum testosterone of castrate monkeys in the normal range for four months. Acta Endocrinol. (Copenh) 113: 128, 1986.
- Marshall GR, Jochenhoevel F, Luedecke DK and Nieschlag E: Maintenance of complete but quantitatively reduced spermatogenesis in hypophysectomized monkeys by testosterone alone. Acta Endocrinol. (Copenh) 113: 424, 1986.
- Rea MA, Marshall GR, Weinbauer GF and Nieschlag E: Testosterone maintains pituitary and serum FSH and spermatogenesis in gonadotropin antagonist-suppressed rats. J. Endocr 108: 101-107,1986.
- Rea MA, Weinbauer GF, Marshall GR and Nieschlag E: Testosterone stimulates pituitary and serum FSH in GnRH /antagonist-suppressed rats. Acta Endocrinol. (Copenh) 113: 487, 1986.
- Huang HFS, Marshall GR, Rosenberg R and Nieschlag E: Restoration of spermatogenesis by high levels of testosterone in hypophysectomized rats after long-term regression. Acta Endocrinol. (Copenh) 116:433-444, 1987.
- Plant T M, Gay V L, Marshall G R, Arslan M: Puberty in monkeys is triggered by chemical stimulation of the hypothalamus. Proc. Natl. Acad. Sci. USA. 86: 2506,1989.
- Abeyawardene SA, Vale WW, Marshall GR, Plant TM: Circulating Inhibin a Concentrations in infant, prepubertal, and adult male rhesus monkeys (Macaca mulatta) and in juvenile males during premature initiation of puberty with pulsatile gonadotropin-releasing hormone treatment. Endocrinology 125: 250, 1989.
- Bellinger M, Abromowitz H, Brantley S, Marshall G: Orchidopexy: An experimental study of the effect of surgical technique on testicular histology. J. Urol. Part 2, 142: 553, 1989.
- Huang HFS, Marshall GR and Nieschlag E: Enrichment of the stages of the seminiferous epithelium in vitamin A- replaced A- deficient rats. J. Reprod. Fertil. 88:51, 1990.
- Attardi B, Marshall GR, Zorub DS, Winters SJ, Miklos J and Plant TM: Effects of Orchidectomy on Gonadotropin and Inhibin Subunit Messenger Ribonucleic Acids in the Pituitary of the Rhesus Monkey (Macaca mulatta)?. Endocrinology 130:1238-1244, 1992.
- Marshall GR, Zorub DS and Plant TM: Follicle stimulating hormone (FSH) amplifies the population of differentiated spermatogonia in testosterone (T) treated, hypophysectomized adult rhesus monkeys (Macaca mulatta). Endocrinology 136:3504-3511, 1995.
- Marshall GR, Plant TM: Puberty occurring either spontaneously or induced precociously in rhesus monkey (Macaca mulatta) is associated with a marked proliferation of Sertoli cells. Biol. Reprod. 54:1192-1199, 1996.
- Winters SJ, Pohl CR, Adedoyin A, and Marshall GR: Effects of continuous inhibin administration on gonadotropin secretion and subunit gene expression in immature and adult male rats. Biol. Reprod. 55:1377-1382, 1996.
- Ramaswamy S, Marshall GR, McNeilly AS and Plant TM. Evidence that in a physiological setting Sertoli cell number is the major determinant of circulating concentrations of inhibin B in the adult male rhesus monkey (Macaca mulatta). J Andrology 20:430-434, 1999.
- Ramaswamy S, Marshall GR, McNeilly AS and Plant TM. Dynamics of the follicle-stimulating hormone (FSH)-inhibin B feedback loop and its role in regulating spermatogenesis in the adult male rhesus monkey (Macaca mulatta) as revealed by unilateral orchidectomy. Endocrinology 141:18-27, 2000.
- Ramaswamy S, Plant TM, and Marshall GR. Pulsatile stimulation with recombinant single chain human luteinizing hormone (schLH) elicits precocious Sertoli cell proliferation in the juvenile male rhesus monkey (Macaca mulatta). Biol. Reprod 63: 82-88, 2000.
- Ravindranath N, Ioffe SL, Marshall GR, Ramaswamy S, Plant TM, and Dym M. Androgen depletion activates telomerase in the prostate of the nonhuman primate, Macaca mulatta. Prostate 49:79-89, 2001.
- Plant TM and Marshall GR. The functional significance of follicle-stimulating hormone in spermatogenesis and the control of its secretion in male primates. Endocr. Rev. 22:764-786, 2001.
- Ramaswamy S, Marshall GR, Pohl CR, Friedman RL. Plant TM. Inhibitory and stimulatory regulation of testicular inhibin B secretion by luteinizing hormone and follicle-stimulating hormone, respectively, in the rhesus monkey (Macaca mulatta). Endocrinology. 144:1175-85, 2003.
- Simorangkir DR, Marshall GR and Plant TM. Sertoli cell proliferation during prepubertal development in the rhesus monkey (Macaca mulatta) is maximal during infancy when gonadotropin secretion is robust. J Clin Endocrinol Metab 88:4984-4989, 2003.
- Marshall GR, Ramaswamy S, Plant TM. Gonadotropin independent proliferation of the pale type A spermatogonia in the adult rhesus monkey (Macaca mulatta). Biol Reprod 73: 222-229, 2005.
- Simorangkir DR, Marshall GR, Ehmcke J, Schlatt S, and Plant TM. Pre-Pubertal Expansion of Dark and Pale Type A Spermatogonia in the Rhesus Monkey (Macaca mulatta) Results from Proliferation During Infantile and Juvenile Development in a Relatively Gonadotropin Independent Manner. Biol Reprod. 73: 1109-1115, 2005.
- Hild SA, Marshall GR, Attardi BJ, Hess RA, Schlatt S, Simorangkir DR, Ramaswamy S, Koduri S, Reel JR, and Plant TM. Development of l-CDB-4022 as a Nonsteroidal Male Contraceptive: Induction and Recovery from Severe Oligospermia in the Adult Male Cynomolgus Monkey (Macaca fascicularis). Endocrinology 148: 1784-1796, 2007. Endocrinology January 11, 2007 as doi:10.1210/en.2006-1487.
- Hild SA, Reel JA, Dykstra MJ, Mann P, and Marshall GR. Acute adverse effects of the indenopyridine, CDB-4022, on the ultrastructure of Sertoli cells, spermatocytes and spermatids in rat testes: Comparison to the known Sertoli cell toxicant, Di-n-pentylphthalate (DPP). J Androl, 28: 621-629, 2007. Online jandrol.106.002295v1 10.2164/jandrol.106.002295.
- Children's Hospital of Pittsburgh Seed Grant (PI) - Role of FSH in Quantitative Maintenance of Spermatogenesis, 7/1/85-6/30/93
- NIH P-30 HD8610-1352 (PI) - Center for Research in Reproductive Physiology, Supplement 2: Spermatogenesis. 12/1/88 -11/30/90
- NIH 2MO1RR00084 (Director, Core Laboratory) - General Clinical Research Center, 12/1/90-11/30/91
- NIH 1RO1 HD32473 (PI), Role of FSH in Spermatogenesis, 8/1/95-07/31/99
- NIH U54 HD08610, (Co-Investigator), Specialized Co-operative Center for Reproductive Research: The Physiology and Pathophysiology of the Primate Gonad, 4/1/2000-3/31/2006
- NIH RO1 DK61536, (Co-Invest), Prevention of Osteoporosis in Men with Prostate Cancer on Androgen Deprivation, 5/12/2002-3/30/2006
- NIH RO1-1-51081, (Co-Invest), Pathophysiology of PTH-related Protein (1-36), 4/1/2003-3/31/2008
- Alumni Scholarship Ohio State University, 1965-1967
- Summer Study Program in Radiation Biology, Argonne National Laboratories, Argonne, Illinois, 1971
- National Institutes of Health Trainee, Department of Biology, Section of Cell Biology, M.D. Anderson Hospital and Tumor Research Institute, Houston, TX , 1970-1973
- Recipient of Predoctoral Fellowship, Department of Human Genetics, Cell Biology and Biochemistry, University of Texas Medical Branch, Galveston, TX, 1973-1974
- Recipient of Predoctoral Fellowship, Department of Reproductive Medicine and Biology, University of Texas Medical School at Houston, Houston, Texas, 1974-1977
- Recipient of National Research Service Award, National Institute of Child Health and Human Development, 1978-1980
- Effects of intermittent GnRH administration in ovariectomized female rhesus monkeys. Sudd. Versuchs und Forschungsanstalt fur Milchwirtschaft, Weihenstephan, F.R. Germany, May, 1981.
- Role of androgens in the regulation of spermatogenesis in non-human primates, University of Texas Medical School at Houston, Houston, Texas, October 28, 1983.
- Initiation, maintenance and restoration of spermatogenesis in non-human primates by testosterone, Deutsches Forschungsgemeinschaft Schwerpunkt Besprechung, Maschoss, F.R. Germany, November 17, 1983.
- Androgen regulation of spermatogenesis in non-human primates, Anatomisches Institute, Abteilung fur Mikroskopische Anatomie, University of Hamburg, Hamburg, F.R. Germany, January 17, 1984.
- Do LHRH - analogs have direct effects on the testes? 2nd Workshop of Pulsatile LHRH Therapy in Man, Celle, F.R. Germany, October 20, 1984.
- The role of gonadotropins in regulation of spermatogonial proliferation and differentiation in adult rhesus monkeys, Bioqual, Inc., Rockville, MD, March, 2004.